Regulation of human nucleus pulposus cells by peptide-coupled substrates
نویسندگان
چکیده
منابع مشابه
Influence of simvastatin on the biological behavior of nucleus pulposus-derived mesenchymal stem cells
Objective(s): This research is to study the influences of different concentrations of simvastatin on the biological activities of nucleus pulposus-derived mesenchymal stem cells (NPMSC).Materials and Methods: NPMSC were cultured with different concentrations of simvastatin (0, 0.01, 0.1, and 1 μM) and assessed to determine the possible e...
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INTRODUCTION The cells of the embryonic notochord play an important role in formation of the spinal column, including the intervertebral discs (IVDs) (1). These cells become trapped inside the annulus fibrosus and reside within the nucleus pulposus at birth, but are generally lost during aging and replaced by small chondrocyte-like cells. The age at which the notochordal cells are lost varies s...
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SIRT1 could protect degenerative human NP cells against apoptosis, and there were extensive and intimate connection between apoptosis and autophagy. Up to now, the role of autophagy in the process of human IVD degeneration is unclear. We sought to explore the relationship between autophagy and human IVD degeneration and to understand whether autophagy is involved in the protective effect of SIR...
متن کاملDegenerate Human Nucleus Pulposus Cells Promote Neurite Outgrowth in Neural Cells
Innervation of nociceptive nerve fibres into the normally aneural nucleus pulposus (NP) of the intervertebral disc (IVD) occurs during degeneration resulting in discogenic back pain. The neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), which are associated with stimulation of axonal outgrowth and nociception by neuronal cells, are both expressed by NP cells,...
متن کاملDifferentiation of Human Ligamentum Flavum Stem Cells Toward Nucleus Pulposus-Like Cells Induced by Coculture System and Hypoxia
STUDY DESIGN Human ligamentum flavum (LF)-derived stem cells (LFSCs) and nucleus pulposus cells (NPCs) were cocultured under normoxia or hypoxia. OBJECTIVE To isolate and identify human LFSCs and determine whether they can differentiate into NPCs when cocultured with NPCs under hypoxia. SUMMARY OF BACKGROUND DATA Mesenchymal stem cell (MSC)-based therapies have been proposed as a biological...
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ژورنال
عنوان ژورنال: Acta Biomaterialia
سال: 2017
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2017.04.019